,
supra shoesAD is an incurable neurodegenerative condition affecting about 18 million people worldwide. The causes of the disease or of the abnormal protein structures seen in AD brains -- amyloid（淀粉体） plaques and neurofibrillary tangles -- are completely unknown.
"This is the first study investigating antiviral effects on AD-like changes and we conclude that since antiviral agents reduce greatly β-amyloid and P-tau levels in HSV1-infected cells, they would be suitable for treating Alzheimer's disease. The great advantage over current AD therapies is that acyclovir would target only the virus, not the host cell or normal uninfected cells. Further, these agents are very safe and are relatively inexpensive.
The study, carried out with Dr Matthew Wozniak and other colleagues in the Faculty of Life Sciences,
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The Manchester team has established that the herpes virus causes accumulation of two key AD proteins -- β-amyloid (Aβ) and abnormally phosphorylated tau (P-tau) -- known to be the main components of plaques and tangles respectively. Both proteins are thought by many scientists to be involved in the development of the disease.
"If these proteins are produced independently of HSV1 replication,
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"The next stage of our research -- subject to funding -- will focus on finding the most suitable antiviral agent -- or combination of two agents that operate via different mechanisms -- for use as treatment. We then need to investigate the way in which the virus and the genetic risk factor interact to cause the disease, as that might lead to further novel treatments.
"Eventually, we hope to begin clinical trials in humans but this is still some way off yet and again will require new funding."
"Our results suggest that HSV1,
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"Also, by targeting a cause of Alzheimer's disease, other viral damage,
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Currently available antiviral agents act by targeting replication of HSV1 DNA,
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"We have found that the viral DNA in AD brains is very specifically located within amyloid plaques,
dolce and gabbana," said Professor Ruth Itzhaki, who led the team in the University's Faculty of Life Sciences. "This, together with the production of amyloid that the virus induces, suggests that HSV1 is a cause of toxic amyloid products and of plaques.
Antiviral drugs（抗病毒药） progression of Alzheimer's disease (AD), a new study shows. The University of Manchester scientists have previously shown that the herpes simplex virus type 1 (HSV1) is a risk factor for Alzheimer's when it is present in the brains of people who have a specific genetic risk to the disease.
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