,
casque dr dreScientists at the University of Dublin,
supra shoes, the Irish National MRSA Reference Laboratory and the University of Dresden and Alere Technologies in Germany identified the new MRSA strain using high throughput DNA microarray screening. Complete genome sequencing revealed that this strain is distinctly different to previously described MRSA. It carries a new type of SCCmec encoding highly divergent（相异的,
casque beats，分歧的） genes that are very different to any described previously in MRSA or in any other organism. Consequently the new strain is not detected as MRSA by routine conventional and real time DNA-based polymerase（聚合酶） chain reaction (PCR) assays commonly used to screen patients for MRSA. The MRSA strain was found to belong to the genetic lineage clonal complex 130 (CC130),
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air jordan, strongly suggesting that the new MRSA originated in animals.
During the publication process,
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A distinctly new type of methicillin（甲氧西林） resistant Staphylococcus aureus (MRSA耐甲氧西林金黄色葡萄球菌) that is not detected by traditional genetic screening methods has been discovered in patients in Irish hospitals according to research to be published in the journal Antimicrobial Agents and Chemotherapy. These findings provide significant insights into how new MRSA strains emerge and highlight the potential for the transmission of infectious agents from animals to humans. MRSA is a significant cause of hospital- and community-acquired infection worldwide. MRSA strains are characterized by the presence of a mobile DNA cassette (known as SCCmec) encoding genes that confer resistance to beta-lactam antibiotics including methicillin and recombinase genes that allow the cassette to transfer into methicillin-susceptible S. aureus (MSSA).
Commenting on the significance of the findings,
michael kors, Professor David Coleman from the University of Dublin said: "The results of our study and the independent United Kingdom study indicate that new types of MRSA that can colonize and infect humans are currently emerging from animal reservoirs in Ireland and Europe and it is difficult to correctly identify them as MRSA. This knowledge will enable us to rapidly adapt existing genetic MRSA detection tests, but has also provided invaluable insights into the evolution and origins of MRSA."
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